Research Projects

Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Tyler Curiel NCI 7R01CA100425-04 8/1/2004 12:00:00 AM 5/31/2009 12:00:00 AM CSCR4/SDF-1 interactions in ovarian cancer pathogenesis
Dir Cost Tot Cost % Prog Dir Prog Tot
194378 283792 100 194378 283792


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Tyler Curiel NCI 5R01CA105207-04 7/27/2005 12:00:00 AM 4/30/2010 12:00:00 AM Plasmacytoid dendritic cell behavior in ovarian cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
187266 273408 100 187266 273408


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Robert Marciniak NIH 5R01AG028129-02 4/15/2007 12:00:00 AM 3/31/2012 12:00:00 AM Oxidative stress, telomere damage and Werner Syndrome
Dir Cost Tot Cost % Prog Dir Prog Tot
200900 293314 100 200900 293314


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Rong Li NCI 5R01CA93506-08 7/1/2002 12:00:00 AM 7/31/2011 12:00:00 AM BRCA1 in gene regulation and tumor suppression
Dir Cost Tot Cost % Prog Dir Prog Tot
169381 247296 100 169381 247296


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Rong Li NIH 5R01DK064604-05 7/1/2004 12:00:00 AM 5/31/2009 12:00:00 AM A novel corepressor of estrogen receptor
Dir Cost Tot Cost % Prog Dir Prog Tot
166880 242783 100 166880 242783


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Rong Li DOD W81XWH-06-1-0340 7/6/2007 12:00:00 AM 7/5/2008 12:00:00 AM BRCA1 function in epithelial-stromal interaction during breast cancer development
Dir Cost Tot Cost % Prog Dir Prog Tot
182896 264440 100 182896 264440


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Thomas Slaga NCI 5R01CA102747-05 8/1/2003 12:00:00 AM 6/30/2009 12:00:00 AM Combined natural inhibitors in skin cancer prevention
Dir Cost Tot Cost % Prog Dir Prog Tot
237045 346086 100 237045 346086


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Thomas Slaga NCI 5R01 CA079065-09 3/1/1998 12:00:00 AM 6/30/2010 12:00:00 AM GR impairment in carcinogenesis: tumor suppressor role
Dir Cost Tot Cost % Prog Dir Prog Tot
225800 299131 100 225800 299131


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Paul Hasty NIH/U. of Maryland Subcontract 5R01ES012512-05 4/1/2007 12:00:00 AM 3/31/2009 12:00:00 AM Role of LIG3 and XRCC1 genes in genome stability
Dir Cost Tot Cost % Prog Dir Prog Tot
5856 8550 100 5856 8550


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Paul Hasty NIH/Buck Inst Subcontract 5P01AG017242-10 5/15/2006 12:00:00 AM 3/31/2009 12:00:00 AM DNA repair, mutations and cellular aging (Project 4)
Dir Cost Tot Cost % Prog Dir Prog Tot
120007 175210 100 120007 175210


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Paul Hasty NCI 5R01CA123203-02 4/1/2007 12:00:00 AM 1/31/2012 12:00:00 AM Discovering TREX1 and TREX2 function in mammalian cells and mice
Dir Cost Tot Cost % Prog Dir Prog Tot
152000 221920 100 152000 221920


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Shou-Jiang Gao NCI 5R01CA096512-05 1/13/2003 12:00:00 AM 12/31/2008 12:00:00 AM Cell model for KSHV infection and genetic manipulation
Dir Cost Tot Cost % Prog Dir Prog Tot
229594 335207 100 229594 335207


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Shou-Jiang Gao NCI 1R01CA132637-01A1 4/1/2008 12:00:00 AM 1/31/2013 12:00:00 AM Mechanism of KSHV-induced angiogenesis
Dir Cost Tot Cost % Prog Dir Prog Tot
207500 307100 100 207500 307100


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Peter Hornsby NIH 5R37AG012287-14 9/30/1994 8/31/2009 Type II 3beta HSD gene Regulation of DHEAS synthesis
Dir Cost Tot Cost % Prog Dir Prog Tot
245809 358881 100 245809 358881


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Peter Hornsby Owens Medical Foundation 11/1/2006 10/31/2009 Improving Cell Therapy
Dir Cost Tot Cost % Prog Dir Prog Tot
15000 15000 100 15000 15000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Peter Hornsby Glenn Foundation for Medical Research 4/1/2008 3/31/2010 Research in the biology of aging
Dir Cost Tot Cost % Prog Dir Prog Tot
60000 60000 100 60000 60000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
S. Austad NIH 5T32AG021890 5/1/2003 12:00:00 AM 4/30/2014 12:00:00 AM Training Program in the Biology of Aging
Dir Cost Tot Cost % Prog Dir Prog Tot
582794 625054 100 582794 625054


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
A. Bishop NIH 5K22 ES12264-03 9/1/2004 12:00:00 AM 5/31/2009 12:00:00 AM A screen for damage response genes using recombination
Dir Cost Tot Cost % Prog Dir Prog Tot
97650 105462 100 97650 105462


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
K. Block NCI 1R01 CA131272-01A2 7/1/2008 12:00:00 AM 5/31/2012 12:00:00 AM Mechanisms of renal carcinogenesis
Dir Cost Tot Cost % Prog Dir Prog Tot
166000 235720 100 166000 235720


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
S. Bose NCI 5R21 CA129246-01A1 5/1/2008 12:00:00 AM 4/30/2010 12:00:00 AM Oncolytic activity of respiratory syncytial virus against prostate cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
112500 166500 100 112500 166500


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
B. Chatterjee VA-Scientist 3/1/2006 12:00:00 AM 2/28/2013 12:00:00 AM Androgen action in the prostate
Dir Cost Tot Cost % Prog Dir Prog Tot
112000 112000 100 112000 112000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
B. Chatterjee VA-MERIT 4/1/2004 12:00:00 AM 9/30/2009 12:00:00 AM Androgen receptor and prostate pathogenesis
Dir Cost Tot Cost % Prog Dir Prog Tot
145000 145000 100 145000 145000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
M. Gaczynska NIH 5R01GM069819-05 2/1/2004 12:00:00 AM 1/31/2009 12:00:00 AM Mechanisms of regulation of the proteasome activities
Dir Cost Tot Cost % Prog Dir Prog Tot
136064 198654 100 136064 198654


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Y. Hu San Antonio Area Foundation 7/9/2008 12:00:00 AM 12/31/2009 12:00:00 AM The mechanism of BRCA1 in tumor suppression
Dir Cost Tot Cost % Prog Dir Prog Tot
35000 35000 100 35000 35000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Y. Hu NCI 5R01CA118578-04 8/1/2006 12:00:00 AM 7/31/2011 12:00:00 AM The mechanism of BRCA1 in tumor suppression
Dir Cost Tot Cost % Prog Dir Prog Tot
189636 276869 100 189636 276869


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
K. Izumi NCI 5R01CA106159-04 6/17/2005 12:00:00 AM 5/31/2010 12:00:00 AM Role of Epstein-Barr virus LMP1 in lymphoma
Dir Cost Tot Cost % Prog Dir Prog Tot
149813 218727 100 149813 218727


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
T. Johnson-Pasi DOD W81XWH-06-1-009 10/30/2005 12:00:00 AM 11/29/2008 12:00:00 AM Amplifications of type II cadherins in prostate cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
124784 182185 100 124784 182185


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
T. Johnson-Pasi DOD W81XWH-07-1-0570 8/1/2007 12:00:00 AM 7/31/2009 12:00:00 AM Identification of chromosome18Q transcripts lost in breast cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
74680 109032 100 74680 109032


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
N. Kirma AICR 07B019-REV 1/1/2007 12:00:00 AM 12/31/2008 12:00:00 AM Chemoprevention of HER-2 positive breast cancer by red wine phytochemicals
Dir Cost Tot Cost % Prog Dir Prog Tot
157500 165000 100 157500 165000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
S. Lee NIH 5R01GM071011-04 4/1/2004 12:00:00 AM 3/31/2009 12:00:00 AM Mechanisms of error prone repair of DNA breaks
Dir Cost Tot Cost % Prog Dir Prog Tot
161191 228085 100 161191 228085


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
S. Lee NIH 1R01GM083010-01A1 7/1/2008 12:00:00 AM 6/30/2012 12:00:00 AM Etiology of chromosome translocations
Dir Cost Tot Cost % Prog Dir Prog Tot
180000 256800 100 180000 256800


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
S. Lee Leukemia & Lymphoma Society 1251-08 7/1/2007 12:00:00 AM 6/30/2009 12:00:00 AM Mechanisms of DNA double-strand break-induced chromosomal translocations
Dir Cost Tot Cost % Prog Dir Prog Tot
105000 105000 100 105000 105000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
F. Liu NIH 5R01DK052933-09 9/16/1997 12:00:00 AM 11/30/2008 12:00:00 AM GRB1 10 isoforms and insulin signaling
Dir Cost Tot Cost % Prog Dir Prog Tot
187740 274100 100 187740 274100


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
F. Liu NIH 1R01DK076902-01A2 4/1/2008 12:00:00 AM 1/31/2013 12:00:00 AM Regulation and function of adiponectin oligomerization
Dir Cost Tot Cost % Prog Dir Prog Tot
202000 298960 100 202000 298960


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Nair Bhaskaran San Antonio Area Foundation 7/1/2007 12:00:00 AM 12/31/2008 12:00:00 AM Targeted therapeutic potential of proapoptotic gene PAR-4 in HER2 overexpressing breast cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
12000 12000 100 12000 12000


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Nair Bhaskaran Elsa U. Pardee Foundation 1/1/2008 12:00:00 AM 12/31/2008 12:00:00 AM Nanoparticle assisted active targeting of gossypin-CLA conjugate in management of breast cancer metastasis
Dir Cost Tot Cost % Prog Dir Prog Tot
86863 108579 100 86863 108579


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
B. Masters NIH 5R01GM052419-12 4/1/1996 12:00:00 AM 3/31/2009 12:00:00 AM Structure/function modularity in nitric oxide synthase
Dir Cost Tot Cost % Prog Dir Prog Tot
183046 274733 100 183046 274733


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
B. Masters NIH 1R01GM081568-01A1 5/21/2008 12:00:00 AM 3/31/2012 12:00:00 AM Molecular & cellular effects of human mutations in cytochrome P450 reductase
Dir Cost Tot Cost % Prog Dir Prog Tot
395753 577170 100 395753 577170


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
H. Rao NIH 5R01GM078085-02 8/1/2007 12:00:00 AM 7/3/2012 12:00:00 AM Targeing ubiquitylated proteins to the proteasome
Dir Cost Tot Cost % Prog Dir Prog Tot
201250 283539 100 201250 283539


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Y. Shilo NIH 5R21AG29587-02 2/15/2007 12:00:00 AM 1/31/2009 12:00:00 AM Quantitative proteomic analysis of HE secretory pattern of senescent cell
Dir Cost Tot Cost % Prog Dir Prog Tot
100450 146657 100 100450 146657


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
Y. Shilo NCI 5R01CA125020-02 9/25/2007 12:00:00 AM 7/31/2011 12:00:00 AM Analysis of the VHL-HIF hydroxylase pathway
Dir Cost Tot Cost % Prog Dir Prog Tot
152000 221920 100 152000 221920


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
O. Pereira-Smith NIH/Subgrant/Walter C.A. 5R01 AG024364-05 9/30/2004 12:00:00 AM 7/31/2008 12:00:00 AM Base excision repair, genetic integrity & health span
Dir Cost Tot Cost % Prog Dir Prog Tot
21488 31374 100 21488 31374


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
O. Pereira-Smith NIH 5R01 AG032134-02 9/1/2007 12:00:00 AM 8/31/2012 12:00:00 AM Role of MRG15 in chromatin changes during cell senescence and in vivo aging
Dir Cost Tot Cost % Prog Dir Prog Tot
205000 299300 100 205000 299300


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
B. Steffensen NIH 5K02 DE016312-05 9/28/2004 12:00:00 AM 8/31/2009 12:00:00 AM MMP-2 in periodontal disease and oral cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
94832 102419 100 94832 102419


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
B. Steffensen NIH 5R01DE017139-03 6/1/2006 12:00:00 AM 5/31/2011 12:00:00 AM MMP-2 and fibronectin fragmentation in periodontal diseases and oral cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
228075 332990 100 228075 332990


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
R. Vadlamudi DOD W81XWH-06-1-0398 3/15/2006 12:00:00 AM 4/14/2009 12:00:00 AM Role of PELP1 in EGFR-ER signaling crosstalk in ovarian cancer cells
Dir Cost Tot Cost % Prog Dir Prog Tot
97459 142290 100 97459 142290


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
C. Walter NIH 5R01AG021163-05 9/1/2002 12:00:00 AM 8/31/2009 12:00:00 AM Germ cell aging
Dir Cost Tot Cost % Prog Dir Prog Tot
286549 401589 100 286549 401589


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
C. Walter NIH 5R01AG024364-05 9/30/2004 12:00:00 AM Base excision repair, genetic integrity & health span
Dir Cost Tot Cost % Prog Dir Prog Tot
248897 323812 100 248897 323812


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
P. Yew NIH 5R01GM066226-05 5/1/2003 12:00:00 AM 1/31/2009 12:00:00 AM CDK inhibitor regulation during the xenopus cycle
Dir Cost Tot Cost % Prog Dir Prog Tot
208486 303774 100 208486 303774


Primary Investigator Funding Agency Grant Number Start Date End Date Project Title
P. Dahia Sidney Kimmel Foundation for Cancer Resaerch 7/1/2007 12:00:00 AM 6/30/2009 12:00:00 AM Energy metabolism and cancer
Dir Cost Tot Cost % Prog Dir Prog Tot
186957 200000 100 186957 200000