Solid Tumors/Non-Hematological

Alisertib (MLN8237)

Description:

Alisertib is orally available small molecule inhibitor of Aurora A kinase that plays important role in cell mitosis. This Phase I study evaluates the effect of food on the pharmacokinetics of Alisertib in patients with advanced solid tumors or lymphomas.


Type(s) of Cancer: Any Solid Tumor
Study Phase(s): Phase I
Category: Solid Tumors/Non-Hematological
Contact: Epp Goodwin at (210) 450-5798

CBL0137

Description:

CBL0137 is a small molecule in the carbazole family affecting p53 and NF-kappa B signal transduction pathways. It is administered intravenously on days 1, 8 and 15 every 28 days in patients with metastatic or advanced solid tumors and refractory lymphomas.


Type(s) of Cancer: Any Solid Tumor
Study Phase(s): Phase I
Category: Solid Tumors/Non-Hematological
Contact: Epp Goodwin at (210) 450-5798