John Sarantopoulos, MD

I am currently a Clinical Research Investigator and Medical Oncologist, with a full-time faculty appointment as Assistant Professor of Medicine in the Division of Hematology-Oncology, Department of Medicine at the NCI-designated Cancer Therapy & Research Center (CTRC) at University of Texas Health Science Center at San Antonio. I am a physician, clinical researcher with an interest and expertise in early antineoplastic drug development, and evaluation for human solid tumors including genitourinary malignancies of renal, prostate, bladder, and melanoma. I am involved with our early therapeutics phase I program, a member of the Experimental Developmental Therapeutics Program and play an important role at the CTRC in attempting to further our mission to prevent, treat, and cure cancer. I have completed an Advance Drug Development Fellowship and I am a Clinical Investigator focusing on early phase I/II trials. I have been a co-PI and PI in over 54 phase I solid tumor studies including first in human studies or first in class compounds, food effect or bioequivalence studies, drug interaction studies, QTc effect studies, and organ dysfunction studies including renal and hepatic impairment. Studies have included NCI CTEP studies and the NCI Organ Dysfunction Working Group, and Co-operative Group trials including the Southwest Oncology Group (SWOG) where I am a member of the Early Therapeutics and GU Committees, as well as Industry-Sponsored, and Cancer Center Investigator- Initiated trials. In addition, I have been a sub investigator in over 139 trials in this area at the CTRC over the last several years. I believe that my education, clinical, and research experiences have demonstrated that I am part of a select group of investigators that can complete such complex early phase trials that are important to the development of new agents for patients with cancer.