Cancer Development and Progression

The major thematic areas of the Cancer Development and Progression (CDP) Program emphasize the historically strong cancer focus at the CTRC as well as new cancer focuses brought to the Center by newly recruited cancer research scientists. The overarching scientific goals of the entire CDP Program are: (1) to integrate basic and applied research aimed at understanding genomic integrity, tumor microenvironment, inflammation, hormone actions and resistance to hormone therapies, and age-related cancer susceptibility; (2) to foster cross-disciplinary collaboration between basic research programs in population studies and experimental therapeutics; and (3) to translate findings of genetic instability, tumor immunity, obesity/nutrition, and hormone resistance into better cancer prevention and treatment. Recent research discoveries made by CDP members not only provide critical mechanistic insight but also have the tremendous potential of leading to new prevention and treatment strategies as well as new diagnostics and /or biomarkers of cancer.