Click on the type of cancer you would like to know more about.
There are two adrenal glands located one above each kidney; your kidneys are found deep inside the upper part of your abdomen. The adrenal cortex makes important hormones that:
There are 2 main types of adrenal cortex tumors:
In most cases, adrenal cortical cancers are much larger than adenomas. If a tumor is larger than about 2 to 2-1/2 inches (5 or 6 centimeters), it is most likely cancer. The cause is unknown. Adrenal cortical carcinoma may be associated with an inherited cancer syndrome. Both men and women develop this tumor, but in women it is more often functional (secreting hormones). Adrenocortical carcinoma is typically an aggressive cancer and is usually found because excess hormone production causes symptoms which prompt patients to seek medical attention. Many patients will present with pain in the abdomen and flank (nearly all that don't present with symptoms of hormone excess will seek medical attention because of pain). Spread to distant organs (metastasis) occurs most commonly to the abdominal cavity, lungs, liver, and bone.
Although potentially curable at early stages, only 30% of these malignancies are confined to the adrenal gland at the time of diagnosis. Because these tumors tend to be found years after they began growing, they have the opportunity to invade nearby organs, spread to distant organs (metastasize) and cause numerous changes in the body because of the excess hormones they produce.
Adrenal cortical carcinomas can produce the hormones cortisol or aldosterone. The average age of those found with adrenal cancer is around 45 to 50, but it can happen at any age, even in children. It seems to occur more often in women.
Review Date: 3/28/2011
Reviewed By: The UT Health Science Center Surgical Oncology Faculty
Some of the hormone problems have specific syndrome/condition names:
The preferred surgical technique is the thoracoabdominal (see image right). This approach allows the greatest exposure to the adrenal gland and all the surrounding structures and entails making a large incision which traverses both the abdominal and thoracic cavities ... including some the diaphragm which separates them. This large operation is reserved for only the largest and most malignant tumors of the adrenal gland in hopes of providing adequate exposure of the tumor and its blood supply to allow curative resection.
Unfortunately, there is no known way to prevent this form of cancer. Scientists have found a few risk factors that make a person more likely to get adrenal cancer, but even if a person does have one or more risk factors for adrenal gland tumors, we can't know for sure how large a part they played in causing the cancer. The cell mutations that occur inside the body cannot be predicted or halted. A parent who had or has adrenal cancer may make a child slightly more likely to develop adrenal cancer from inherited DNA that causes adrenal cancer cell division, but even a genetic predisposition to adrenal cancer has not been definitively proven.
The outcome is dependent on how early the diagnosis is made and whether the tumor has spread (metastasized). It is hard to find adrenal cancer early. In most cases the tumor has grown quite large before it is found. It is often found earlier in children than in adults because children react more to the hormones these tumors make. In adults, these tumors may be found early by accident, for example when a CT scan is done for some other health problem. These tumors are often fatal within a few years.